Long-term use of melatonin supplements may pose health risks
Research Overview
A five-year review of health data from more than 130,000 adults with chronic insomnia who had taken melatonin for at least one year showed increased odds of heart failure diagnosis, hospitalization due to the condition, and a higher risk of death from all causes.
"Long-term use of melatonin supplements, often used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization, and death from any cause in chronic insomnia."
Study Context
These preliminary findings will be presented at the American Heart Association’s Scientific Sessions 2025, a leading international forum for new discoveries and updates in cardiovascular medicine. The conference will run from November 7 to 10 in New Orleans.
About Melatonin
Melatonin is a hormone produced by the pineal gland that regulates the body’s sleep-wake rhythm. Its levels rise after dark and drop during daylight. Synthetic melatonin, which replicates the natural hormone, is often taken to treat insomnia and jet lag.
Supplement Use and Regulation
Melatonin supplements are commonly sold over the counter in many countries, including the United States. In the U.S., such supplements do not undergo government quality or consistency checks, and their dosage and purity can differ widely between brands.
Key Takeaway
While melatonin can help with sleep regulation, extended use appears linked to higher cardiovascular risks and deserves cautious medical oversight.
Author’s summary: Prolonged melatonin use for insomnia may raise heart failure and mortality risks, highlighting the need for careful supplement regulation and medical guidance.