NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Week 6 Predictions
Last week's NFL bold predictions went 2-1, resulting in a +1.17 unit overall gain. Since Week 3, picks in this story are up 2.16 units.
3 Bold Predictions for Week 6
Fading the Colts offense may not be the wisest choice, but there's a case for doing so. Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if they maintain this pace all season.
Author's summary: NFL Week 6 predictions and picks.