Long-Term Melatonin Use May Increase Heart Risks
New research suggests that using melatonin supplements for extended periods to address sleep problems could pose serious heart-related dangers. Chronic melatonin users were found to have nearly double the risk of death and 3.5 times the risk of hospitalization due to heart failure.
Study Findings Presented at AHA 2025
A preliminary study shared at the American Heart Association's Scientific Sessions 2025 revealed that adults with chronic insomnia who took melatonin for a year or more faced greater chances of developing heart failure, requiring hospitalization for heart failure, and increased mortality compared to those not using melatonin.
This research was featured at the AHA’s annual conference held November 7-10 in New Orleans, a pivotal event for cardiovascular research and clinical updates.
About Melatonin
Melatonin is a hormone produced by the pineal gland that regulates the body's sleep-wake cycle.
Its natural production increases in darkness and decreases in daylight. Synthetic melatonin, identical to the natural hormone, is commonly used worldwide to treat insomnia and jet lag.
Supplement Availability and Concerns
Melatonin supplements are available over the counter in many countries, including the U.S. However, because these supplements are not strictly regulated in the U.S., their purity and dosage can vary significantly, raising concerns about safety with long-term use.
Expert Warning
Despite melatonin’s reputation as a safe remedy, experts now recommend caution with prolonged consumption due to its potential cardiovascular risks.
Summary: Long-term melatonin use, though common and often considered safe, may increase risks of heart failure and death, prompting experts to advise caution.