Common Supplement Shows Concerning Link to Heart Failure

New Study Links Long-Term Melatonin Use to Heart Risks

Recent research on melatonin, a widely used sleeping aid, raises concerns about its safety when used for extended periods. An analysis involving over 130,000 adults with insomnia from several countries found that those prescribed melatonin for more than one year had significantly higher heart-related risks.

Key Findings

"The findings are preliminary and do not currently change health recommendations," the researchers stated, emphasizing the need for caution.

Context and Implications

Melatonin is the fourth most popular natural supplement in the US and is generally considered safe for short-term use (about 1 to 2 months), especially among non-pregnant and non-breastfeeding adults. However, there is limited research on its long-term effects.

The new study highlights the urgent need for more research to evaluate the safety of prolonged melatonin use as the supplement's popularity continues to rise. These findings were shared at the American Heart Association's Scientific Sessions.

Additional Information

The results do not prove that melatonin directly causes heart problems but suggest caution and further investigation.

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ScienceAlert ScienceAlert — 2025-11-07