Melatonin Use Linked to Higher Heart Failure Risk
A new study suggests that adults with insomnia who take melatonin regularly for over a year may face a 90% greater risk of developing heart failure compared to nonusers. These individuals are also at increased risk of hospitalization or death within five years.
Key Findings
- Researchers analyzed over 130,000 adults with insomnia and no prior history of heart failure.
- Participants who used melatonin for more than one year faced a 90% higher chance of heart failure.
- They were almost 3.5 times more likely to be hospitalized for the condition compared with nonusers.
- In the United Kingdom, those who had at least two melatonin prescriptions 90 days apart showed an 82% higher risk.
"Long-term use of melatonin appears to significantly raise the risk of heart failure and other serious outcomes in adults with insomnia," noted the researchers at the American Heart Association Scientific Sessions 2025.
Widespread Use of Melatonin
Melatonin remains among the most popular over-the-counter sleep aids in the United States. Nearly six million Americans use it to fall asleep more quickly or to improve sleep quality. However, the findings highlight the potential dangers of prolonged use and call for more cautious, medically guided consumption.
Health Experts’ Concerns
Experts emphasize that while melatonin can help manage temporary sleep issues, long-term reliance without medical oversight might expose users to cardiovascular risks. They recommend patients consult healthcare providers before continuing extended use.
Author Summary
Long-term melatonin consumption for insomnia may greatly elevate heart failure and mortality risks, prompting calls for medical guidance and careful use.